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. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Heredity (Edinb). 2010 Mar 17;105(1):45–56. doi: 10.1038/hdy.2010.23

Figure 1.

Figure 1

Three examples of mouse imprinted gene clusters showing imprinted expression in the embryo and/or adult versus placenta. (a) Igf2r cluster: imprinted silencing on the paternal chromosome is initiated by the Airn macro ncRNA. (b) Kcnq1 cluster: imprinted silencing on the paternal chromosome is initiated by the Kcnq1ot1 macro ncRNA. (c) Igf2 cluster: imprinted silencing on the maternal chromosome is initiated by CTCF binding the unmethylated ICE forming an insulator that blocks access to enhancers. Protein-coding genes and ncRNAs showing imprinted expression are shown as pink (maternally expressed) and blue (paternally expressed), with genes showing no parental allelic difference in gray. ICE, imprint control element; M, DNA methylation; and E, enhancer.