Table 3.
Differentially regulated genes involved in G2-M phase transition.
| Symbol | Gene Name | Wt | Xpc-/- |
|---|---|---|---|
| Arl4* | ADP-ribosylation factor-like 4 | 1.15 | 1.20 |
| Asf1b* | ASF1 anti-silencing function 1 homolog B | 1.24 | 1.25 |
| Ccnb2 | cyclin B2 | -1.24 | -1.16 |
| Cdc25c | cell division cycle 25 homolog C (S. cerevisiae) | -1.09 | -1.30 |
| Cdc42ep4 | CDC42 effector protein (Rho GTPase binding) 4 | 1.33 | 1.29 |
| Cdca8 | cell division cycle associated 8 | -1.24 | -1.11 |
| Cit* | citron | 1.20 | 1.35 |
| Cks2* | CDC28 protein kinase regulatory subunit 2 | 1.29 | 1.36 |
| Ect2* | ect2 oncogene | 1.25 | 1.45 |
| Got1 | glutamate oxaloacetate transaminase 1, soluble | 1.24 | 1.24 |
| Gpsm2* | G-protein signalling modulator 2 (AGS3-like) | 1.23 | 1.33 |
| Kpna2 | karyopherin (importin) alpha 2 | 1.35 | 1.30 |
| Map3k6* | mitogen-activated protein kinase kinase kinase 6 | 1.25 | 1.35 |
| Psip1* | PC4 and SFRS1 interacting protein 1 | 1.17 | 1.30 |
| Rrm1* | ribonucleotide reductase M1 | 1.18 | 1.22 |
| Tacc3* | transforming, acidic coiled-coil containing protein 3 | 1.31 | 1.34 |
| Tdp1 | tyrosyl-DNA phosphodiesterase 1 | 1.28 | 1.21 |
| Tubd1* | tubulin, delta 1 | 1.26 | 1.30 |
Gene expression ratios are presented of 18 differentially regulated genes involved in G2 to M phase transition based on microarray results. These 18 genes, of which 3 were down regulated and 15 were up regulated after B[a]P exposure, showed a trend towards a more pronounced induction in Xpc-/- mice as compared to Wt mice (p = 0.086). However, a less extensive down regulation is not the same as a greater induction. Therefore, an additional p-value was calculated for the 15 up regulated genes, showing that 11 (indicated with *) out of these 15 up regulated genes are more induced in Xpc-/- than in Wt mice (p = 0.024).