Table 1. Ratio of cholesterol density averaged inside the first (0.4–0.8 nm) and the second (0.8–1.1 nm) coordination shells with respect to the total mean density.

DSPC +	10% Chol	20% Chol	30% Chol	40% Chol	40% Dchol	50% Chol
0.4–0.8 nm	0.253	0.228	0.277	0.480	0.441	0.670
0.8–1.1 nm	1.49	1.24	1.40	1.46	1.52	1.44

We have used 1.1 nm to define the range of the second coordination shell around cholesterol. To avoid any contribution from the third coordination shell, all measures of the second coordination shell were conducted between 0.8–1.1 nm.