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. 2010 Jun 17;6(6):e1000821. doi: 10.1371/journal.pcbi.1000821

Figure 2. The five categories of ABAC pairs.

Figure 2

For each pair of complexes, one structure is displayed in pink and the other in green, with the superimposed A/A′ domains on the left side and the B/C domains on the right side. Images are generated using Pymol [78]. Structural mimicry, alternate loop conformations and residue insertion/deletion are highlighted by thicker representations. Hereafter, complexes are named by their PDB code (first four letters), combined with the identifiers of interacting chains (last two letters). A: category O, PDB structure 1dg1_HG (dimer of domain 2 of elongation factor Tu of E. coli) versus PDB structure 1g7c_AB (domain 2 of elongation factor eEF-1 alpha from S. cerevisiae complexed with guanine nucleotide exchange factor domain from elongation factor-1 beta), B: category M, PDB structure 1avw_AB (trypsin from pig complexed with soybean trypsin inhibitor) versus PDB structure 1fak_BD (human coagulation factor VIIa complexed with bovine pancreatic trypsin inhibitor), C: category E, PDB structure 1wq1_RG (human cH-p21 Ras protein complexed with p120GAP domain) versus PDB structure 1gzs_AB (human CDC42 complexed with GEF domain of SopE toxin from S. typhimurium), D: category I, PDB structure 1bui_AC (catalytic domain of human plasmin complexed with staphylokinase from S. aureus) versus PDB structure 1gl0_BA (bovine chymotrypsinogen complexed with protease inhibitor PMP-D2V from L. migratoria), E: category S, PDB structure 1p8j_HE (N-terminal domain of murine furin complexed with C-terminal domain of furin) versus PDB structure 1ic6_AB (dimer proteinase K from T. album).