Table I.
Absolute lymphocyte subset concentrations by age in venous blood from healthy Malawians
| Age groups | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Subset | 0-6 mo (n = 58) |
6-12 mo (n = 51) |
12-18 mo (n = 46) |
18-24 mo (n = 45) |
2-3 y (n = 46) |
3-5 y (n = 42) |
5-10 y (n = 52) |
10-15 y (n = 49) |
15-20 y (n = 51) |
20-60 y (n = 49) |
>60 y (n = 50) |
P value for linear trend∗ |
| Male:female | 21:37 | 20:31 | 27:19 | 29:16 | 27:19 | 21:21 | 26:26 | 14:35 | 26:25 | 23:26 | 22:28 | |
| Total leukocytes | 9.4 | 9.7 | 10.95 | 9.4 | 8.0 | 8.2 | 6.5 | 5.7 | 5.2 | 5.0 | 5.65 | <.001 |
| (6.2, 15.3) | (8.1, 14.2) | (7.1, 15.7) | (6.5, 13.2) | (6.5, 11.5) | (6.6, 9.8) | (4.7, 10.8) | (3.9, 8.1) | (3.7, 7.3) | (3.9, 7.2) | (4.35, 6.95) | ||
| Total lymphocytes | 5.45 | 6.3 | 7.0 | 5.4 | 4.25 | 3.7 | 3.1 | 2.8 | 2.1 | 2.0 | 2.4 | <.001 |
| (3.7, 9.2) | (4.5, 9.6) | (4.4, 9.3) | (3.55, 7.4) | (2.7, 6.0) | (2.6, 5.1) | (2.2, 4.9) | (1.9, 3.8) | (1.7, 3.2) | (1.4, 2.9) | (1.75, 2.95) | ||
| B lymphocytes | 1.5 | 1.8 | 1.9 | 1.3 | 1.0 | 0.7 | 0.5 | 0.4 | 0.3 | 0.2 | 0.2 | <.001 |
| (CD19+) | (0.7, 2.8) | (1.2, 2.9) | (1.0, 3.5) | (0.7, 2.4) | (0.5, 1.5) | (0.4, 1.3) | (0.3, 0.8) | (0.2, 0.7) | (0.2, 0.5) | (0.1, 0.3) | (0.1, 0.4) | |
| T lymphocytes | 3.4 | 3.9 | 4.0 | 3.3 | 2.9 | 2.4 | 2.1 | 1.9 | 1.5 | 1.4 | 1.6 | <.001 |
| (CD3+) | (2.2, 6.1) | (2.7, 5.6) | (2.1, 5.5) | (2.4, 4.8) | (1.7, 4.5) | (1.8, 3.7) | (1.4, 3.4) | (1.3, 2.7) | (1.1, 2.4) | (0.9, 2.1) | (1.2, 2.2) | |
| CD4+ T lymphocytes | 2.0 | 2.2 | 2.2 | 1.8 | 1.7 | 1.4 | 1.2 | 1.1 | 0.9 | 0.8 | 1.0 | <.001 |
| (CD3+CD4+) | (1.3, 4.2) | (1.6, 3.3) | (1.2, 3.9) | (1.2, 2.7) | (1.0, 2.6) | (0.9, 2.0) | (0.8, 2.1) | (0.8, 1.7) | (0.6, 1.2) | (0.5, 1.2) | (0.6, 1.3) | |
| CD8+ T lymphocytes | 1.0 | 1.4 | 1.4 | 1.3 | 1.0 | 0.9 | 0.8 | 0.7 | 0.6 | 0.6 | 0.5 | <.001 |
| (CD3+CD8+) | (0.6, 2.1) | (0.8, 2.3) | (0.8, 2.3) | (0.7, 2.0) | (0.6, 1.6) | (0.6, 1.5) | (0.5, 1.2) | (0.4, 1.1) | (0.4, 1.0) | (0.3, 1.0) | (0.3, 0.9) | |
| γδT lymphocytes | 0.2 | 0.2 | 0.3 | 0.2 | 0.2 | 0.2 | 0.2 | 0.1 | 0.1 | 0.1 | 0.1 | <.001 |
| (CD3+TCRγδ+) | (0.1, 0.4) | (0.1, 0.5) | (0.1, 0.7) | (0.1, 0.4) | (0.1, 0.4) | (0.1, 0.4) | (0.1, 0.3) | (0.1, 0.3) | (0.1, 0.2) | (0.0, 0.2) | (0.0, 0.1) | |
| NK cells | 0.4 | 0.4 | 0.4 | 0.3 | 0.3 | 0.3 | 0.3 | 0.3 | 0.3 | 0.3 | 0.4 | .54 |
| (CD3-CD16/56+) | (0.2, 1.0) | (0.2, 0.7) | (0.2, 1.2) | (0.2, 0.7) | (0.2, 0.8) | (0.1, 0.6) | (0.1, 0.9) | (0.1, 0.6) | (0.1, 0.5) | (0.1, 0.7) | (0.2, 0.8) | |
Values are medians (10th and 90th centiles) × 103 cells/μL venous blood.
∗
Calculated by using actual ages in months.