Table 4.

Transcription factor motif gene sets enriched in the promoter region of the genes downregulated in the 2,297-probe HFSC signature as described in MSigDB (GSEA molecular signatures database). ^aHFSC OFF: genes underexpressed in HFSC that contain within their promoter region a binding motif for that transcription factor; Total, refers to the total number of targets in the expression array. NES: Normalized enrichment score, for repressed genes in a given dataset (HFSC) NES values are negative; FDR: False discovery rate

Gene or family	Motif gene sets	aHFSC OFF / Total	NES	FDR q-val
E2F transcription factor	E2F_Q4	75 / 165	−2.35	<0.0001
	E2F_Q3_01	80 / 166	−2.17	<0.0001
	E2F1_Q6	68 / 163	−2.14	<0.0001
	E2F1DP1RB_01	68 / 160	−2.23	<0.0001
RB, Retinoblastoma	E2F4DP2_01	67 / 162	−1.87	0.003
DP1, E2F dimerization partner 1	E2F1DP2_01	67 / 162	−1.86	0.003
DP2, E2F dimerization partner 2	E2F4DP1_01	66 / 167	−1.82	0.004
	E2F1DP1_01	67 / 162	−1.85	0.003
	SGCGSSAAA_E2F1DP2_01	52 / 117	−2.00	0.001
	GTGACGY_E4F1_Q6	193 / 447	−2.00	0.001
Nuclear respiratotry factor	NRF2_01	93 / 165	−2.26	<0.0001
	GABP_B	98 / 159	−2.17	0.001
	NRF1_Q6	76 / 159	−1.98	0.001
ETS transcription factor	TEL2_Q6	74 / 156	−2.11	<0.0001
	ETS_Q4	83 / 178	−2.07	<0.0001
	ELK1_01	87 / 176	−1.97	0.001
	ELK1_02	93 / 170	−1.78	0.006
	CETS1P54_01	72 / 176	−1.76	0.007
Yin yang transcription factor 1	GCCATNTTG_YY1_Q6	148 / 296	−1.87	0.003