Table 1.
Genes inactivated in the identified mutants
Attenuated mutants were identified by screening an STM library. The mutants were tested individually for attenuation.
| Clone | M. avium gene | Function |
|---|---|---|
| STM1/STM7 | MAV_2450 | Polyketide synthase 12 |
| STM2 | MAV_3321 | ABC transporter, ATP-binding subunit |
| STM3 | MAV_3105 | Polyketide synthase 11 |
| STM4 | MAV_2723 | PAP A2 condensation domain |
| STM5 | MAV_4292 | Hypothetical protein |
| STM6 | MAV_0385 | N-Acetylmuramyl-l-alanine amidase |
| STM8 | MAV_1346 | PE family protein |
| STM9 | MAV_4366 | Chaperonin GroES |
| STM10 | MAV_4012 | Conserved hypothetical protein |
| STM11 | MAV_4264 | Hypothetical protein, homology with bacterial regulatory protein TetR domain |