Table 2.
Multivariate Adjusted Cox Proportional Hazards of Graft Loss in a Single-Center Study of 668 Kidney Transplants
| All Patients | Death-Censored | |||
|---|---|---|---|---|
| Variable | Hazard Ratio | p Value | Hazard Ratio | p Value |
| Donor age (continuous) | 0.98 (0.97–1.00) | NS | 0.99 (0.97–1.01) | NS |
| Recipient age (continuous) | 1.00 (0.98–1.01) | NS | 0.98 (0.97–1.00) | NS |
| African-American race versus non-African- American race (donor) |
0.95 (0.59–1.69) | NS | 0.81 (0.45–1.47) | NS |
| African-American race versus non- African- American race (recipient) |
1.21 (0.73–2.02) | NS | 1.21 (0.69–2.13) | NS |
| Hypertension (yes versus no) | 1.03 (0.51–2.09) | NS | 1.22 (0.56–2.67) | NS |
| Diabetes mellitus (yes versus no) | 0.58 (0.32–1.06) | NS | 0.76 (0.40–1.44) | NS |
| Number of HLA mismatch (continuous) | 1.24 (1.08–1.44) | <0.01 | 1.29 (1.10–1.52) | <0.01 |
| Cold ischemia time (continuous) | 0.99 (0.97–1.02) | NS | 0.99 (0.96–1.02) | NS |
| Warm ischemia time (continuous) | 1.00 (0.99–1.02) | NS | 1.00 (0.98–1.01) | NS |
| Peak PRA (≥50 versus <50) | 1.13 (0.66–1.92) | NS | 0.84 (0.45–1.55) | NS |
| Previous kidney transplant (yes versus no) | 1.27 (0.64–2.52) | NS | 1.61 (0.79–3.28) | NS |
| Donor type (deceased versus living donor) | 1.10 (0.52–2.31) | NS | 1.26 (0.55–2.89) | NS |
| 30-day acute rejection (yes versus no) | 5.72 (2.16–15.12) | <0.01 | 5.10 (1.67–15.5) | <0.01 |
| Donor BMI >2 units compared to recipient versus others |
0.94 (0.58–1.52) | NS | 0.84 (0.49–1.44) | NS |
| Male donor-female recipient versus others | 1.78 (1.12–2.85) | 0.02 | 1.97 (1.18–3.30) | 0.01 |
HLA, human leukocyte antigen; PRA, panel-reactive lymphocytotoxic antibody.