Table 3.
Multivariate Adjusted Cox Proportional Hazards of Death-Censored Graft Loss in a Single Center Study of 392 Male Recipients and 276 Female Recipients
| Male Recipients | Female Recipients | |||
|---|---|---|---|---|
| Variable | Hazard Ratio | p Value | Hazard Ratio | p Value |
| Donor age (continuous) | 0.99 (0.97–1.02) | NS | 0.99 (0.96–1.02) | NS |
| Recipient age (continuous) | 0.98 (0.96–1.01) | NS | 0.97 (0.94–1.00) | NS |
| African-American race versus non-African- American race (donor) |
0.44 (0.13–1.55) | NS | 0.63 (0.27–1.46) | NS |
| African-American race versus non- African-American race (recipient) |
1.75 (0.66–4.63) | NS | 1.20 (0.47–3.06) | NS |
| Hypertension (yes versus no) | 1.01 (0.31–3.24) | NS | 2.71 (0.64–11.40) | NS |
| Diabetes mellitus (yes versus no) | 0.52 (0.15–1.85) | NS | 1.34 (0.57–3.15) | NS |
| Number of HLA mismatch (continuous) | 1.31 (0.99–1.75) | 0.03 | 1.44 (1.10–1.87) | 0.01 |
| Cold ischemia time (continuous) | 1.03 (0.99–1.07) | NS | 0.95 (0.90–0.99) | 0.02 |
| Warm ischemia time (continuous) | 0.98 (0.95–1.00) | NS | 1.01 (0.99–1.04) | NS |
| Peak PRA (≥50 versus <50) | 1.68 (0.48–5.82) | NS | 0.42 (0.17–1.04) | NS |
| Previous kidney transplant (yes versus no) | 0.66 (0.18–2.48) | NS | 4.46 (1.43–13.8) | 0.01 |
| Donor type (deceased versus living donor) | 0.60 (0.14–2.64) | NS | 2.67 (0.55–12.9) | NS |
| 30-day acute rejection (yes versus no) | 13.5 (2.44–74.5) | <0.01 | 1.49 (0.24–9.29) | NS |
| Male donor BMI >2 units compared to recipient versus others |
1.86 (0.72–4.81) | NS | 0.19 (0.05–0.67) | 0.01 |
| Male donor versus female donor | 0.91 (0.35–2.33) | NS | 3.45 (1.40–8.51) | 0.01 |
HLA, human leukocyte antigen; PRA, panel-reactive lymphocytotoxic antibody.