Table 3.

Developmental endpoints in pregnancy cohort studies and population surveys

Table legend: Data at birth represent all analysis beginning at ∼5 lunar months of pregnancy, Growth abnormalities are those born <2500 grams, Functional abnormalities represent those with an abnormal neurological exam at 1 year of age, Structural abnormalities are those identifiable by an examination of the infant over the first 4 years of life, Death includes those born at 5 or more lunar months (includes stillbirth, perinatal deaths and those who were “fresh stillbirths”), Neonatal deaths are those born alive who died in the first 30 days of life, Premature are those born less than 37 completed weeks of pregnancy.

Pregnancy Cohort or Population Studied	Growth	Structure	Function	Death	Premature
British Perinatal Mortality Survey (1958) ∼17,000 births (96, 97)
Developmental Endpoints at birth in singleton pregnancies	6.7%	2.4%		3.6%	9.4%
Not walking by 18 months			4.3%
Not talking by 2 years			6%
Developmental endpoints at 7 years		3.7%		5.2%
USA Collaborative Perinatal Project (1959 – 1965) ∼50,000 births (38, 98, 99)
Developmental Endpoints at Birth in singleton pregnancies	10.4%	4.5%	1.7%	8.7%	17.7%
Developmental endpoints at 1 year		15.6%		9.5%
Developmental endpoints at 7 years		20.2%		10.0%
Developmental Endpoints at Birth, Florida linked datasets (1997 – 1998) (2)
Developmental endpoints at birth in singleton pregnancies	8%	2.4%
Abnormal condition			6.7%
Developmental delay or disability			2.1%