Table 1.
In Vitro Cell Growth Inhibitory Effects of Compounds 3g, 4g,h,k,l,o,p, and CA-4 (1)
| compd | IC50a(nM) |
|||||
|---|---|---|---|---|---|---|
| HeLa | A549 | HL-60 | Jurkat | K562 | MCF-7 | |
| 3g | >10000 | >10000 | 6200 ± 1200 | 93 ± 30 | 3600 ± 900 | 7400 ± 1200 |
| 4g | 250 ± 50 | 1100 ± 100 | 90 ± 6 | 300 ± 80 | > 10000 | 540 ± 20 |
| 4h | 280 ± 60 | 520 ± 90 | 120 ± 10 | 50 ± 10 | 950 ± 40 | 360 ± 50 |
| 4k | 150 ± 20 | 800 ± 50 | 500 ± 20 | 50 ± 10 | 340 ± 50 | 390 ± 90 |
| 4l | 15 ± 4 | 100 ± 20 | 20 ± 3 | 5 ± 0.2 | 20 ± 8 | 50 ± 9 |
| 4o | 6 ± 2 | 10 ± 5 | 3 ± 0.2 | 3 ± 0.6 | 20 ± 10 | 17 ± 1 |
| 4p | 600 ± 20 | >10000 | 700 ± 200 | 650 ± 60 | 800 ± 100 | 610 ± 10 |
| CA-4 | 4 ± 1 | 180 ± 50 | 1 ± 0.2 | 5 ± 0.6 | 5 ± 0.1 | 370 ± 100 |
a
IC50: compound concentration required to inhibit tumor cell proliferation by 50%. Data are expressed as the mean ± SE from the dose–response curves of at least three independent experiments.