TABLE I. AVN944-Induced Expression of Differentiation Markers in DU145 and PC-3 Cells.
| Gene | DU145 | PC-3 |
|---|---|---|
| CAV1 | 6.0 | 1 |
| CC3 | 33.2 | 20.0 |
| CD10 | 6.3 | 5.0 |
| CD55 | 15.0 | 2.4 |
| CEACAM5 | 11.6 | 25.8 |
| CPA4 | 17.7 | 1 |
| CTSB | 5.6 | 1 |
| Cyr61 | 1 | 4.9 |
| GAL | 2.5 | 1 |
| GDF15 | 12.8 | 32.1 |
| GLA | 2364.72 | 30.4 |
| GRP78 | 3.6 | 1 |
| KLK5 | 46.1 | 16.2 |
| KRT2 | 18.4 | 4.3 |
| KRT4 | 2315.42 | 1033.52 |
| KRT6B | 5.4 | 1 |
| KRT19 | 5.9 | 1 |
| LGALS3 | 12.3 | 2.2 |
| MIG6 | 3.2 | 4.9 |
| NDRG1 | 5.9 | 19.4 |
| TNFSF9 | 5.2 | 3.9 |
Expression levels of studied genes were normalized to those of RPS25.
1
The change in the mRNA level was in the interval 1.0–1.7.
2
Ct for the mock-treated cells were set arbitrarily to 50, which represents a number of cycles ran during the qRT-PCR analysis.