Fig. 5.

An integrated analysis of cyclin B1, cyclin D1, and cyclin E1 expression in breast cancer. In human breast tumor cohort B, cyclin B1, cyclin D1, and cyclin E1 protein expression levels were integrated in the heat map. This analysis defined three large breast cancer subgroups (i, ii and iii) that were associated with significantly different outcomes in all breast tumors and when the analysis was confined to ER-positive (ER+) breast cancers only (color coding matches each subgroup name to the corresponding survival curves). The cyclins were quantified using RPPA and quantification data were log 2 transformed and mean centered for clustering in the heat map.