Table 1.

Association between cyclin protein expression and clinical variables in 195 hormone receptor–positive breast cancers obtained at primary surgery from patients treated subsequently with only adjuvant tamoxifen

	Patient number	Mean RPPA expression	95% confidence interval (RPPA)		P
			Lower	Upper
Cyclin B1
Stage					0.82
I	45	−0.33	−0.73	0.07
II	117	−0.27	−0.46	−0.07
III	32	−0.16	−0.6	0.28
Histology					0.08
Ductal	171	−0.2	−0.37	−0.02
Lobular	15	−0.83	−1.24	−0.42
Mucinous	8	−0.63	−1.29	0.03
Grade					0.001
1	49	−0.84	−1.13	−0.55
2	60	−0.17	−0.44	0.11
3	9	0.13	−0.55	0.82
PR					0.72
Negative	53	−0.22	−0.51	0.08
Positive	142	−0.28	−0.48	−0.09
Cyclin D1
Stage					0.07
I	45	0.27	0.07	0.47
II	117	0.26	0.13	0.4
III	32	0.6	0.28	0.93
Histology					0.87
Ductal	171	0.33	0.22	0.45
Lobular	15	0.33	0.08	0.74
Mucinous	8	0.19	−0.14	0.51
Grade					0.56
1	49	0.24	0.03	0.45
2	60	0.39	0.19	0.59
3	9	0.24	−0.1	0.58
PR					0.58
Negative	53	0.27	0.07	0.47
Positive	142	0.34	0.21	0.47
Cyclin E1
Stage					0.18
I	45	−0.36	−0.53	−0.19
II	117	−0.23	−0.33	−0.14
III	32	−0.14	−0.3	0.01
Histology					0.33
Ductal	171	−0.24	−0.32	−0.16
Lobular	15	−0.44	−0.7	−0.18
Mucinous	8	−0.16	−0.37	0.04
Grade					0.357
1	49	−0.34	−0.48	−0.19
2	60	−0.25	−0.39	−0.1
3	9	−0.5	−0.85	−0.15
PR
Negative	53	−0.19	−0.33	−0.05
Positive	142	−0.27	−0.36	−0.18	0.35

NOTE: The cyclins were quantified using RPPA and the quantification data were expressed in log 2 form for analysis with the clinical variables shown. Note that numbers may not add up to 195 in any particular category because of missing data.