Table 3.
Conversions without Fusion
| Tissue / Cell | Model / Detection | Reference |
|---|---|---|
| Pancreas | Rosa – stop lox and GFP female hosts transplanted with insulin-dependent Cre-male marrow. No GFP+ donor cells in islets. |
92 |
| Hepatocyte | Human cord blood to irradiated NOD/SCID mouse. Human hepatocytes with positive protein and chromosome markers, no mouse chromosomes. Conversion rate 1–2%. |
93 |
| Hepatocyte | Human cord blood (USSC) into fetal sheep without injury. 20% conversion rate. Microdissected human hepatocytes had only human protein or PCR product. |
94 |
| Endothelial | c-kit+, Sca-1+, Lin- into irradiated mouse. Donor endothelia in portal vein. Normal ploidy. Also cord blood to mouse with new blood vessel formation in the eye-no fusion. |
95 |
|
Renal Mesangial Cells |
Male GFP marrow to male mice resulted in numerous GFP+ mesangial cells. None had more than one Y chromosome. |
96 |
|
Epithelial Cells in Lung, Skin, and Liver |
Cre/lox recombinase system. Transplant Z/EG marrow into Cre expressing mice. No mice expressed GFP indicated that fusion had not occurred. |
97 |
| Skeletal Muscle | Converted mononucleated satellite cells preceed muscle fiber fusion. |
80 |