Table 1.

Potential Risk Factors for SCD in HCM

History of SCD

Family history of premature death

“Malignant” causal mutations

“Malignant” modifier genes

History of syncope

Magnitude of left ventricular hypertrophy

Extent of myocyte disarray

Extent of interstitial fibrosis

Early onset of the disease

Myocardial ischemia on perfusion tomography

Abnormal blood pressure response to exercise

Presence of nonsustained VT on Holter

HCM = hypertrophic cardiomyopathy; SCD = sudden cardiac death; VT = ventricular tachycardia.