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B6.mdr1a−/− and FVB.mdr1a−/− colonic histology. Representative examples of histology and histological scores are given for B6 and FVB P-gp deficient mice at 2 (A–C), 5 (D–F), 8 (G–I), and 12 (K–L) months of age. Images captured at 100X magnification. Bar=100µm.* Indicates statistical significance of P<0.05 as determined by Mann Whitney analysis. Values were significantly different when compared both between P-gp deficient strains, and when compared to control strains.
