Table 3.
Isolated systolic hypertension and other outcomes in matched participants
| Outcomes | Rate, per 10,000 person-years follow-up (% events) |
Rate difference* (per 10,000 person-years) | Hazard ratio (95% confidence interval) | P value | |
|---|---|---|---|---|---|
| Isolated systolic hypertension | |||||
| No (n =1260) | Yes (n =1260) | ||||
| All-cause mortality | 401 (35) | 398 (35) | −3 | 1.03 (0.88–1.19) | 0.732 |
| Coronary artery disease | 181 (15) | 240 (19) | + 59 | 1.34 (1.08–1.66) | 0.008 |
| Acute myocardial infarction | 95 (8) | 125 (10) | + 30 | 1.33 (0.99–1.77) | 0.057 |
| Angina pectoris | 154 (13) | 209 (17) | + 55 | 1.38 (1.09–1.74) | 0.006 |
| Cerebrovascular disease | 150 (13) | 199 (16) | + 49 | 1.33 (1.05–1.67) | 0.017 |
| Stroke | 125 (11) | 164 (14) | + 39 | 1.32 (1.03–1.70) | 0.028 |
| Transient ischemic attack | 28 (3) | 39 (4) | + 11 | 1.67 (0.97–2.86) | 0.064 |
| Peripheral arterial disease | 37 (3) | 28 (2) | −9 | 0.84 (0.50–1.41) | 0.508 |
*
Absolute rate differences were calculated by subtracting the rates of new events in the no isolated systolic hypertension group from those in the isolated systolic hypertension group (before values were rounded).