Skip to main content
. Author manuscript; available in PMC: 2011 Jan 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2010 Apr 8;30(7):1453–1459. doi: 10.1161/ATVBAHA.110.205666

Figure 4. Contribution of endogenous TRPC5 and TRPC1.

Figure 4

Data are from intracellular Ca2+ measurements from VSMCs. (a, b) Responses to 3 μM PGPC after pretreatment with anti-TRPC antibody alone or anti-TRPC antibody preadsorbed to its antigenic peptide (+pep.) (N=5 each): T5E3 anti-TRPC5 antibody (a); T1E3 anti-TRPC1 antibody (b). (c) As for (a, b) but mean data for independent experiments (n/N=3/15). (d, e) As for (a, c) but using POVPC instead of PGPC (n/N=3/15). (f) Example from 8 independent paired experiments of the response to 3 μM PGPC after transfection with dominant negative mutant TRPC5 (DN-TRPC5) or vector control (N=16 for each).