Figure 9. The effect of IL-23 administration on response to intranasal LVS infection.

WT C57BL/6 mice were infected intranasally with a lethal dose of 10×LD₅₀. (A) shows the effects on mice survival of systemic intraperitoneal administration of IL-23 or carrier only at the day of infection with 10×LD₅₀. The time of death of each animal is shown; (B) shows the results of intranasal administration of IL-23 or carrier only at the day of infection with 10×LD₅₀. (C) depicts the effects of intranasal administration of IL-23 in naïve mice. 24 h after instillation of IL-23 (black bars) or PBS carrier (gray bars), BALFs were harvested from three individual animals and the concentrations of selected cytokines were determined. Results show the mean concentration values; * represents statistical significance of P value <0.05, ** represents statistical significance of P value <0.01. Figure shows the result of a representative experiment out of three performed. In the other experiments, each mice group included 5-6 mice.