Table 2.

Intracohort (rows) comparisons of lifetime prevalence of prescription opioid-use disorder

	Age ranges (n)		Disorder, % [95% CI]
Birth cohort	NLAES 1991–1992	NESARC 2001–2002	NLAES 1991–1992	NESARC 2001–2002	Intracohort difference a
Lifetime disorder in the overall population
1974–1983	—	18–27 (7,168)	—	1.4 [1.1, 1.8]	—
1964–1973	18–27 (7,746)	28–37 (8,527)	0.8 [0.6, 1.0]	1.3 [1.0, 1.6]	62.5%**
1954–1963	28–37 (10,221)	38–47 (8,840)	1.1 [0.8, 1.3]	2.0 [1.6, 2.3]	81.8%***
1944–1953	38–47 (7,820)	48–57 (6,862)	0.9 [0.6, 1.1]	1.0 [0.7, 1.3]	11.1%
1934–1943	48–57 (5,056)	—	0.3 [0.2, 0.5]	—	—
Total (1944–1973)	38–47 (7,820)	28–57 (24,229)	0.9 [0.8, 1.1]	1.4 [1.3, 1.6]	55.5%***
Lifetime disorder among lifetime users
1974–1983	—	18–27 (255)	—	36.5 [29.1, 44.0]	—
1964–1973	18–27 (269)	28–37 (266)	24.6 [18.8, 30.4]	37.6 [30.4, 44.7]	52.8%**
1954–1963	28–37 (398)	38–47 (332)	26.3 [21.2, 31.5]	47.3 [40.5, 54.0]	79.8%***
1944–1953	38–47 (237)	48–57 (177)	30.6 [23.6, 37.6]	39.6 [31.2, 48.1]	29.4%
1934–1943	48–57 (57)	—	31.1 [17.2,45.2]	—	—
Total (1944–1973)	18–47 (692)	28–57 (775)	26.9 [23.5, 30.3]	42.4 [32.1, 48.7]	57.6%***

Notes: NLAES = National Longitudinal Alcohol Epidemiologic Survey; NESARC = National Epidemiologic Study on Alcohol and Related Conditions.

^aDifference between 2001-2002 (NESARC) and 1991-1992 (NLAES) lifetime prevalence estimates for a given birth cohort.

^**p <.01;

^***p < .001.