Table 3.

Correlation between targeting frequencies and distance to or density of genomic elements

Genomic element	Distancea		Densityb
			Interval size
	bp	Natural log bp	±1 kb	±10 kb	±100 kb
	Correlation coefficient, r	Correlation coefficient, r	Correlation coefficient, r	Correlation coefficient, r	Correlation coefficient, r
RefSeq transcripts	0.01	−0.15	0.15	−0.03	0.02
CpG islandsc	−0.23	−0.21	0.00	0.04	−0.17
Simple repeats	−0.11	−0.13	0.05	0.39	0.32
Microsatellites (all)c	−0.33	−0.37	n/ad	0.31	0.34
SINEs	−0.12	−0.03	−0.04	0.25	0.07
LINEs	−0.07	−0.08	0.17	−0.01	−0.05
DNA transposons	0.03	0.05	−0.17	0.10	0.17
LTR retrotransposons	−0.23	−0.18	−0.18	0.29	0.26
RNA repeats	0.21	0.19	n/a	n/a	−0.28

^aDistance was measured from bp 37 of the neo gene in the MLV target locus to the center of the nearest respective genomic element, with the exception of RefSeq transcripts, where distance was measured to the start site of the nearest RefSeq transcription unit; correlation coefficients were computed using either distance (in bp) or the natural logarithm of distance.

^bDensity was measured as the total number of base pairs covered by the corresponding genomic element within a given interval surrounding the target integration site.

^cSee Figure 3 for representative scatter plots.

^dn/a denotes the absence of specified genomic element within given interval.