Figure 2.

SOX10, MITF and JUN transcription factors are regulated in melanoma and associated with mutations in RAS and RAF. E-values of TFactS-predicted TF regulations for each NCI60 cell line are transformed into scores [−log10(E-value)]. These scores were plotted by cancer type (A) or by pathway mutations (B) for SOX10, MITF and JUN. Mutations clustered into RAF-RAS pathway targeted BRAF, KRAS, HRAS and NRAS. P-values were obtained by Kruskal–Wallis test (A) and Student’s t-test (B). WT, ‘wild type’; MUT, ‘mutant’; BR, breast; CNS, central nervous system; CO, colon; LC, lung cancer; LE, leukemia; ME, melanoma; OV, ovarian; PR, prostate; RE, renal.