Figure 9. Basolateral adrenaline induced a sustained positive short circuit current (I_sc) in mouse (NMRI) distal colonic mucosa.

The tissue was clamped to 0 mV and the basolateral side exposed to a high K⁺ concentration (123.6 mm). Luminal iberiotoxin (IBTX, 120 nm) inhibited the major fraction of the positive I_sc. The residual positive I_sc was blocked by 5 mm luminal BaCl₂. * indicates statistical significance between pre-control I_sc values and those after addition of adrenaline. # indicates statistical significance between the adrenaline-induced I_sc values (7 min post-stimulation) and those after addition of iberiotoxin (n= 5).