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. Author manuscript; available in PMC: 2011 May 21.
Published in final edited form as: Org Lett. 2010 May 21;12(10):2182–2185. doi: 10.1021/ol100495w

Table 1.

Substrate scope of o-QM mediated [4+4] reaction

graphic file with name nihms196954u2.jpg
entry pdt R1 R2 yield (%)a
1 2a H 2-OMe Bn 71
2 2b H 2,3-Cl CH2Ph 73
3 2c 4-Br nBu 90
4 2d 4-Br iBu 91
5 2e 4-Br PMB 82
6 2f 4-Br cyclopropyl 81
7 2g 4-Br propargyl 94
8 2h 5-Cl Allyl 94
9 2i 5-Cl PMB 71
10 2j 5-Cl 3-F Bn 93
11 2k 5-Cl 2-OMe Bn 87
12 2-l 4-Br (iPr)CHCO2Me 93
13 2m 4-Br (iBu)CHCO2Me 77
[a]

isolated yield after column chromatography