Table 1.
Selected general and clinical characteristics of the study sample according to Lipoprotein[a] quartiles (N=1002).
| Characteristics | Lipoprotein[a] quartiles (range, mg/dl) | ||||
|---|---|---|---|---|---|
| Variables | I (0-3.5) (N=251) |
II (3.6-12.3) (N=250) |
III (12.4-32.8) (N=249) |
IV (32.9-175.9) (N=252) |
P* |
| Age (mean±SD) (Years) | 74.0±7.3 | 74.1±7.6 | 73.3±6.7 | 74.3±7.2 | .432 |
| Men | 43.8% | 44.8% | 43.0% | 44.4% | .978 |
| Smokers | |||||
| Former | 30.5% | 27.1% | 24.5% | 26.2% | |
| Current | 15.1% | 13.2% | 15.7% | 13.1% | .787 |
| Alcohol consumption (g/day) | |||||
| 0-20 | 47.0% | 44.0% | 47.0% | 46.0% | |
| >20 | 24.7% | 28.8% | 25.4% | 25.2% | .972 |
| Physical activity level scale [1-7, 7=best], (mean±SD) |
3.2 ±0.98 | 3.2±0.95 | 3.3±0.88 | 3.2±1.02 | .516 |
| Body Mass Index (Kg/m2,mean±SD ) | 27.2±4.0 | 27.8±4.0 | 27.4±4.2 | 27.6±3.8 | .293 |
| Hypertension | 62.2% | 60.0% | 62.7% | 62.3% | .928 |
| Positive Rose Questionnaire | 14.4% | 24.4% | 28.9% | 32.2% | .080 |
| Diabetes mellitus | 13.9% | 11.6% | 12.1% | 9.9% | .578 |
| Coronary Heart Disease (Angina or myocardial infarction) |
8.0% | 8.8% | 10.8% | 15.1% | .046 |
| Stroke or Transient Ischemic Attack (%) | 7.2% | 4.8% | 6.4% | 7.9% | .533 |
| Statins therapy | 0.4% | 2.0% | 3.6% | 7.9% | <.001 |
| Total Cholesterol (mg/dl, mean±SD) | 215.3±41.4 | 215.3±38.4 | 217.6±36.6 | 227.0±38.2 | .0015 |
| Low-density lipoprotein-cholesterol (mg/dl, mean±SD) |
132.6±36.7 | 135.0±33.2 | 137.3±31.3 | 144.2±32.7 | <.001 |
| High-density lipoprotein-cholesterol (mg/dl, mean±SD) |
56.3±16.7 | 54.1±14.2 | 55.0±14.4 | 57.8±14.3 | .029 |
| Oxidized low-density lipoprotein-cholesterol (U/l, mean±SD) |
41.4±13.3 | 42.9±12.6 | 42.7±11.8 | 42.9±12.9 | .435 |
| Triglycerides (mg/dl, median-iqr) | 105(81-161) | 117(84-161) | 112(85-148) | 108(88-146) | .709 |
| Creatinine clearance (mL/min) | 77.5±27.1 | 78.8±25.8 | 76.9±25.2 | 75.2±24.9 | .487 |
| High sensitivity-C-reactive protein (μg/ml, median- iqr) |
2.44(1.11-4.92) | 2.36 (1.27-5.51) | 2.82 (1.36-5.83) | 2.99 (1.53-5.57) | .151 |
| Interleukin-6 (pg/ml, median-iqr) | 1.38 (0.78-2.01) | 1.47 (0.88-2.36) | 1.44 (0.84-2.09) | 1.38 (0.86-2.27) | .629 |
| Fibrinogen (mg/dl, median-iqr) | 345 (308-390) | 340 (302-390) | 345 (312-395) | 360 (318-413) | .007 |
| Interleukin-1 receptor antagonist (pg/ml, median- iqr) |
127(95-175) | 136 (101-192) | 137 (93-190) | 134 (95-180) | .472 |
| Homocysteine (μmol/L, media-iqr) | 14.8 (12.2-17.5) | 14.6 (12.0-17.3) | 14.4 (11.9-17.9) | 13.5 (11.7-16.5) | .176 |
| Estimated creatinine clearance (ml/min, mean±SD) | 64.9 ±20.8 | 65.6 ±19.1 | 64.4 ±18.4 | 63.9 ±18.3 | .784 |
*
P value from ANOVA, Chi-square test, or Kruskal-Wallis nonparametric test for variables with skewed distribution