Figure 1.
(A) Systolic blood pressure (SBP). HT, hypertension; NE, norepinephrine; AngII, Angiotensin II; -NAME, Nω-nitro--arginine methyl ester. Values are mean±s.e. n=15 in each group. (B) Kaplan–Meier plot of signs of stroke. n=15 in each group. (C) Sagittal section through brain of chronic/acute HT-AngII mouse. Arrows indicate spontaneous ICH in (1) cerebral cortex, (2) thalamus, (3) upper brainstem, and (4) cerebellum. Bar: 5 mm. (D and E) Hematoxylin and eosin staining of brain sections with spontaneous ICH in thalamus of chronic/acute HT-AngII mouse. (D) Confluent ICH. (E) Patchy ICH. Bar: 200 μm. (F) Number and (G) volume of spontaneous ICH per mouse. n=6 in chronic/acute HT-NE mice and n=11 in chronic/acute HT-AngII mice. *P<0.05.