Figure 5.
Ablation of PGC-1α alters short-term plasticity of evoked IPSCs but not basal GABA release. A, Representative traces of sIPSCs (blocked by the GABAA receptor antagonist PTX) in +/+ and −/− animals. Quantification of spontaneous IPSCs revealed that the IPSC frequency and amplitude were not different between genotypes. B, Paired-pulse depression was reduced in PGC-1α −/− mice. Example IPSCs are the average of 15 traces with stimulus artifacts blanked for clarity (left). Reduced paired-pulse depression was seen at the 20 and 30 ms interstimulus intervals (right, n = 12 per interval). Mann–Whitney U tests. *p < 0.05.