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. Author manuscript; available in PMC: 2011 Feb 1.
Published in final edited form as: Cell Cycle. 2010 Feb;9(3):601–611. doi: 10.4161/cc.9.3.10606

Figure 8.

Figure 8

A hypothesized model for KLF8 mediated transcription. KLF8 binds to a GT box within the promoter of its cyclin D1 target gene through its DNA binding domain (DBD). Its activation domain (AD) is located between the DBD and its repression domain (RD). The AD possesses two glutamine residues (Q118 and Q248) that are essential for recruitment of the p300, CBP and PCAF co-activators to acetylate the histones for promoter activation. We hypothesize that p300 and/or PCAF, but not CBP, may acetylate KLF8. We propose that when CBP binds to KLF8, the p300/PCAF interaction with KLF8 and subsequent acetylation on KLF8 may be blocked.