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. Author manuscript; available in PMC: 2010 Jun 21.
Published in final edited form as: Synlett. 2009 May;8(2009):1189–1207. doi: 10.1055/s-0029-1216654

Table 12.

Synthesis of three contiguous stereocenters via the asymmetric Stetter reaction. graphic file with name nihms-199310-t0190.jpg

Entry R Substrate Product Yield % ee%
1 graphic file with name nihms-199310-t0191.jpg graphic file with name nihms-199310-t0192.jpg 86 >99
2 graphic file with name nihms-199310-t0193.jpg graphic file with name nihms-199310-t0194.jpg 71 99
3 graphic file with name nihms-199310-t0195.jpg graphic file with name nihms-199310-t0196.jpg 80 >99
4 graphic file with name nihms-199310-t0197.jpg graphic file with name nihms-199310-t0198.jpg 62 >99
5a graphic file with name nihms-199310-t0199.jpg graphic file with name nihms-199310-t0200.jpg 64 99
6a,b graphic file with name nihms-199310-t0201.jpg graphic file with name nihms-199310-t0202.jpg 60 90
a

Reaction proceeds in > 95:5 dr.

b

The free carbene was used.