. Author manuscript; available in PMC: 2010 Jun 21.

Published in final edited form as: Synlett. 2009 May;8(2009):1189–1207. doi: 10.1055/s-0029-1216654

Table 8.

Formation of quaternary stereocenters from aromatic aldehydes via the asymmetric Stetter reaction. graphic file with name nihms-199310-t0117.jpg

Entry	Yield %	ee%
1	96	97
2	92	89
3	95	99
4	95	92
4	95^a	92^a
5	54	87
5	83^a	98^a
6	33	88
6	91^a	99^a
7	11	82
7	15^a	82^a
8^b	55	99
9	0	---
9	11^c	>99^c

KOt-Bu was used as the base.

Catalyst added in two portions.

Catalyst 40 was used.