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. Author manuscript; available in PMC: 2011 May 15.
Published in final edited form as: Biochem J. 2010 Apr 28;428(1):75–84. doi: 10.1042/BJ20090977

Figure 2. Functional interaction of free-KCNE1-CT with KCNQ1 channels.

Figure 2

(A) Schematic Diagram of KCNQ1 and KCNE1 channel subunits with cylinders representing predicted α-helices. (B) Voltage clamp current traces (elicited by depolarizing voltage steps) of KCNQ1 alone, KCNQ1/KCNE1-CT, KCNQ1/KCNE1 and KCNQ1/KCNE1/KCNE1-CT channels expressed in CHO cells. (C) Deactivation rates plotted against voltage from CHO cells expressing KCNQ1 either without KCNE1, or with KCNE1, KCNE1-CT, or with both KCNE1 and KCNE1-CT. (D) Normalized voltage-dependence of activation curves from same cells as in panel C.