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SPR results for KCNQ1 C-terminal domains and mutants binding to Immobilized KCNE1 C-terminus
| Q1CT | Kd (μM) | Rmax (RU) |
|---|---|---|
| Q1Cf | 3.2 ± 0.7 | 4729 ± 391 |
| Q1C1 | 4.6 ± 1.4 | 1202 ± 162 |
| Q1C1 A371T | 6.5 ± 0.7 | 3039 ± 161 |
| Q1C1 Q357R | 2.4 ± 0.9 | 1011 ± 129 |
| Q1C1 R366W | Nd* | 178 ± 39 |
| Q1C1 S373P | 7.0 ± 1.9 | 4586 ± 627 |
| Q1C1 T391I | * ND | 213 ± 10 |
| Q1C1 W392R | * ND | 25 ± 4 |
| Q1C1A | * ND | 56 ± 9.1 |
| Q1C1B | 2.4 ± 0.6 | 936 ± 75 |
| Q1C2 | * ND | <25 |
| Q1C3 | * ND | <25 |
ND Not determined due to low interaction signal.
