Fig. 6.

HA sequence alignment of H5 and seasonal 'flu (H1 and H3) at the position of RI-10/KI-10 CTL epitope. The sequence of RI-10/KI-10 and their relevant sequence in H1 and H3 are shaded grey. Circles show that all of these sequences have a conserved leucine at position 2 and a valine or isoleucine at the C terminals, suggesting that they all have a typical HLA-A2-binding motif. However, central parts of RI-10/KI-10 in H5 and the relevant positions in seasonal 'flu (H3 and H1) are largely different.