Table 1.
Aerosol transmission of CWD in Tg(cerPrP) mice
+, Present; − not present.
| Animal no. | Neurological signs* | Survival (days p.i.) | Weight loss (% max. body wt) | PrPCWD WB | PrPCWD IHC | TSE lesions |
|---|---|---|---|---|---|---|
| Sham n=5 | − | 411–749 | 2 (average) | − | − | − |
| 384 | + | 411 | 31 | + | + | + |
| 746 | + | 417 | 32 | + | + | + |
| 739 | + | 457 | 35 | − | − | − |
| 732 | + | 524 | 27 | + | + | + |
| 734 | + | 563 | 31 | + | + | + |
| 738 | − | 708 | 11 | − | + | − |
| 380 | + | 749 | 12 | + | + | + |
*Animals were considered positive if they exhibited at least three of the following symptoms: ataxia, lethargy, tremors, weight loss, poor coat quality or rigid tail.