Table 3.

Patients' demographics, autoimmune profile and co-morbidities by disease category

Characteristics of patients (P-value1)	ACA+/SS (n = 20) [%]	SSc/(+) sicca (n = 31) [%]	SSc/(-) sicca (n = 20) [%]	ACA-/SS (n = 61) [%]
Sex(0.558)
female	20 [100.0]	28 [90.3]	19 [95.0]	57 [93.4]
male	0 [0.0]	3 [9.7]	1 [5.0]	4 [6.6]
P-values2		0.271	1.000	0.567
Smoking (0.603)	4 [20.0]	5 [16.1]	2 [10.0]	14 [23.0]
P --values2		0.703	0.661	1.000
Anti-Ro (<0.0001)	6 [30.0]	4 [12.9]	0 [0.0]	43 [70.5]
P-values2		0.163	0.020	0.003
Anti-La (<0.0001)	3 [15.0]	2 [6.5]	0 [0.0]	25 [41.0]
P-values2		0.369	0.231	0.056
ANA (0.006)	20 [100.0]	31 [100.0]	20 [100.0]	51 [83.6]
P-values2		-	-	0.060
Anti-U1RNP (0.558)	0 [0.0]	3 [9.7]	1 [5.0]	4 [6.6]
P-values2		0.271	1.000	0. 567
Anti-Sm (0.721)	0 [0.0]	1 [3.2]	0 [0.0]	2 [3.3]
P-values2		1.000	-	1.000
Anti-Scl70 (0.172)	0 [0.0]	2 [6.5]	1 [5.0]	0 [0.0]
P-values2		0.514	1.000	-
Th. Hashimoto (0.023)	1 [5.0]	4 [12.9]	0 [0.0]	15 [24.6]
P-values2		0.636	1.000	0.102
Autoim. Hepatitis (-)	0 [0.0]	0 [0.0]	0 [0.0]	0 [0.0]
P-values2		-	-	-
Atr. gastritis (0.422)	2 [10.0]	2 [6.5]	0 [0.0]	2 [3.3]
P-values2		0.640	0.487	0.254
PBC (0.209)	3 [15.0]	3 [9.7]	0 [0.0]	3 [4.9]
P-values2		0.668	0.231	0.157
Celiac (0.209)	0 [0.0]	0 [0.0]	0 [0.0]	1 [1.6]
P-values2		-	-	1.000
Lymphoma (0.476)	0 [0.0]	2 [6.5]	0 [0.0]	2 [3.3]
P-values2		0.514	-	1.000
Death (0.059)	0 [0.0]	3 [9.7]	1 [5.0]	0 [0.0]
P-values2		0.271	1.000	-

¹ Overall P-value from the Chi Square test of independence (significance < 0.05).

² P-values from the Fisher's exact test comparing the first group with each of the other three groups

PBC, primary biliary cirrhosis