Table 1.
IL18 gene polymorphisms in a series of biopsy-proven GCA and matched controls
|
IL18
Polymorphisms |
GCA patients Number (%) |
Healthy controls Number (%) |
||
|---|---|---|---|---|
| -137 (G->C) (rs187238) | Number = 212 | Number = 403 | P value | OR (95% CI) |
| G/G | 106 (50.0) | 224 (55.6) | Reference | - |
| G/C | 94 (44.3) | 159 (39.4) | 0.20 | 1.25 (0.87-1.79) |
| C/C | 12 (5.7) | 20 (5.0) | 0.53 | 1.27 (0.56-2.84) |
| G | 306 (72.2) | 607 (75.3) | Reference | - |
| C | 118 (27.8) | 199 (24.7) | 0.23 | 1.18 (0.89-1.55) |
| -607 (C->A) (rs1946518)a | Number = 212 | Number = 405 | P value | OR (95% CI) |
| C/C | 53 (24.9) | 129 (31.9) | Reference | - |
| C/A | 116 (54.7) | 220 (54.3) | 0.21 | 1.28 (0.85-1.94) |
| A/A | 43 (20.4) | 56 (13.8) | 0.02 | 1.87 (1.09-3.21) |
| C | 221 (52.2) | 478 (59.1) | Reference | - |
| A | 203 (47.8) | 332 (40.9) | 0.02 | 1.32 (1.04-1.69) |
| -1297 (T->C) (rs360719)b | Number = 212 | Number = 405 | P value | OR (95% CI) |
| T/T | 99 (46.7) | 237 (58.5) | Reference | - |
| T/C | 96 (45.3) | 150 (37.0) | 0.02 | 1.53 (1.07-2.20) |
| C/C | 17 (8.0) | 18 (4.4) | 0.02 | 2.26 (1.063-4.82) |
| T | 294 (69.3) | 624 (77.0) | Reference | - |
| C | 130 (30.7) | 186 (23.0) | 0.003 | 1.48 (1.13-1.95) |
aGenotype distribution for the IL18 -607 (C->A) polymorphism: P = 0.054.
bGenotype distribution for the IL18 -1297 (T->C) (rs360719): P = 0.011.
Genotype frequencies for the IL18 -607 (C->A) (rs1946518) polymorphism: IL18 -607 A/A homozygous versus IL18 -607 C/A plus IL18 -607 C/C: P = 0.04; OR, 1.59; 95% CI, 1.02-2.46.
Genotype frequencies for the IL18-1297 (T->C) (rs360719) polymorphism: IL18-1297 C/C plus IL18-1297 T/C genotypes compared to IL18-1297 T/T genotype: P = 0.005; OR, 1.61; 95% CI, 1.15-2.25.