Table 3.
Association with disease severity measures in early rheumatoid arthritis and in autoantibody-positive/antibody-negative disease
| RA cohort | Erosions | Swollen joint count | Health Assessment Questionnaire | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Erosive, n (%) | Per-allele OR (95% CI) | P trend adj. a | Mean (95% CI) | Coefficient (95% CI) | P trend adj.a | Mean (95% CI) | Coefficient (95% CI) | P trend adj.a | |
| HLA-DRB1 shared epitope | 554 (21.5) | n = 587 | n = 587 | ||||||
| Negative | 175 (22.9) | 0.88 | 0.398 | 10.5 (9.5 to 11.5) | -0.03 | 0.455 | 1.35 (1.24 to 1.47) | -0.00 | 0.965 |
| One copy | 278 (20.9) | (0.65 to 1.19) | 9.4 (8.7 to 10.1) | (-1.04 to 0.47) | 1.38 (1.29 to 1.46) | (-0.09 to 0.09) | |||
| Two copies | 101 (20.8) | 9.7 (8.4 to 11.0) | 1.27 (1.14 to 1.41) | ||||||
| PTPN22 (rs2476601) | 580 (20.7) | n = 468 | n = 468 | ||||||
| GG | 423 (22.0) | 0.75 | 0.189 | 9.5 (8.8 to 10.2) | -0.02 | 0.593 | 1.32 (1.23 to 1.40) | 0.06 | 0.133 |
| GA | 147 (17.0) | (0.48 to 1.16) | 9.0 (7.8 to 10.1) | (-1.31 to 0.75) | 1.43 (1.30 to 1.56) | (-0.03 to 0.21) | |||
| AA | 10 (20.0) | 10.4 (1.9 to 18.9) | 1.48 (0.35 to 2.61) | ||||||
| OLIG3/TNFAIP3 (rs6920220) | 551 (20.3) | n = 468 | n = 468 | ||||||
| GG | 302 (19.9) | 1.03 | 0.853 | 9.4 (8.6 to 10.1) | 0.04 | 0.291 | 1.36 (1.27 to 1.45) | -0.01 | 0.880 |
| GA | 217 (20.7) | (0.73 to 1.46) | 9.3 (8.3 to 10.2) | (-0.39 to 1.31) | 1.36 (1.24 to 1.48) | (-0.11 to 0.09) | |||
| AA | 32 (21.9) | 10.5 (7.7 to 13.3) | 1.07 (0.76 to 1.37) | ||||||
| STAT4 (rs7574865) | 476 (20.4) | n = 468 | n = 468 | ||||||
| GG | 271 (22.1) | 0.82 | 0.291 | 9.5 (8.7 to 10.2) | 0.01 | 0.873 | 1.38 (1.28 to 1.47) | -0.06 | 0.193 |
| GT/ | 170 (18.2) | (0.57 to 1.19) | 9.3 (8.2 to 10.3) | (-0.82 to 0.97) | 1.35 (1.23 to 1.46) | (-0.17 to 0.04) | |||
| TT | 35 (17.1) | 9.5 (7.0 to 12.0) | 1.12 (0.85 to 1.39) | ||||||
| TRAF1/C5 (rs10760130) | 474 (20.3) | n = 468 | n = 468 | ||||||
| AA | 140 (16.4) | 1.18 (0.86 to 1.61) | 0.311 | 9.7 (8.6 to 10.8) | -0.03 | 0.502 | 1.25 (1.11 to 1.38) | 0.09 | 0.031 |
| GA | 225 (22.7) | 9.1 (8.3 to 9.9) | (-1.07 to 0.52) | 1.34 (1.24 to 1.43) | (0.01 to 0.19) | ||||
| GG | 109 (20.2) | 9.6 (8.4 to 10.8) | 1.50 (1.35 to 1.65) | ||||||
CI, confidence interval; OR, odds ratio; RA, rheumatoid arthritis. aAdjusted for symptom duration (all cases having a symptom duration <24 months).