Table 2.
Frequencies of gene polymorphisms with or without cardiovascular events: 5 years follow up
| Polymorphism | Cardiovascular event occurrence in RA patients | |||||
|---|---|---|---|---|---|---|
| Overall | 5 years follow up | |||||
| + | - | P value | + | - | P value | |
| MTHFR 1298 A>C | (n = 77) | (n = 511) | (n = 75) | (n = 484) | ||
| AA | 29 (37.7) | 257 (50.3) | Ref. | 29 (38.7) | 241 (49.8) | Ref. |
| AC | 36 (46.8) | 206 (40.3) | 0.10 | 34 (45.3) | 193 (39.9) | 0.16 |
| CC | 12 (15.6) | 48 (9.4) | 0.03 | 12 (16.0) | 50 (10.3) | 0.04 |
| A | 94 (61.0) | 720 (70.5) | Ref. | 92 (61.3) | 675 (69.7) | Ref. |
| C | 60 (39.0) | 302 (29.5) | 0.02 | 58 (38.7) | 293 (30.3) | 0.04 |
| MTHFR 677 C>T | (n = 76) | (n = 523) | (n = 75) | (n = 492) | ||
| CC | 38 (50.0) | 219 (41.9) | Ref. | 38 (50.7) | 210 (42.7) | Ref. |
| CT | 28 (36.8) | 247 (47.2) | 0.11 | 27 (36.0) | 225 (45.7) | 0.12 |
| TT | 10 (13.2) | 57 (10.9) | 0.98 | 10 (13.3) | 57 (11.6) | 0.87 |
| C | 104 (68.4) | 685 (65.5) | Ref. | 103 (68.7) | 645 (65.5) | Ref. |
| T | 48 (31.6) | 361 (34.5) | 0.48 | 47 (31.3) | 339 (34.5) | 0.45 |
Data presented as n (%). Genotypic and allelic frequencies of the 1298 A>C and 677 C>T 5,10-methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms in rheumatoid arthritis (RA) patients with (+) or without (-) cardiovascular events in the whole cohort and in patients with 5 years of follow up. Ref., reference.