Table 3.
Frequencies of gene polymorphisms with or without cardiovascular events: 10 years follow up
| Cardiovascular event occurrence in RA patients | ||||||
|---|---|---|---|---|---|---|
| Overall | 10 years follow up | |||||
| + | - | P value | + | - | P value | |
| MTHFR 1298 A>C | (n = 77) | (n = 511) | (n = 64) | (n = 335) | ||
| AA | 29 (37.7) | 257 (50.3) | Ref. | 22 (34.4) | 160 (47.8) | Ref. |
| AC | 36 (46.8) | 206 (40.3) | 0.10 | 30 (46.9) | 142 (42.4) | 0.15 |
| CC | 12 (15.6) | 48 (9.4) | 0.03 | 12 (18.8) | 33 (9.9) | 0.01 |
| A | 94 (61.0) | 720 (70.5) | Ref. | 74 (57.8) | 462 (69.0) | Ref. |
| C | 60 (39.0) | 302 (29.5) | 0.02 | 54 (42.2) | 208 (31.0) | 0.01 |
| MTHFR 677 C>T | (n = 76) | (n = 523) | (n = 63) | (n = 347) | ||
| CC | 38 (50.0) | 219 (41.9) | Ref. | 31 (49.2) | 152 (43.8) | Ref. |
| CT | 28 (36.8) | 247 (47.2) | 0.11 | 24 (38.1) | 153 (44.1) | 0.37 |
| TT | 10 (13.2) | 57 (10.9) | 0.98 | 8 (12.7) | 42 (12.1) | 0.87 |
| C | 104 (68.4) | 685 (65.5) | Ref. | 86 (68.3) | 457 (65.9) | Ref. |
| T | 48 (31.6) | 361 (34.5) | 0.48 | 40 (31.7) | 237 (34.1) | 0.64 |
Data presented as n (%). Genotypic and allelic frequencies of the 1298 A>C and 677 C>T 5,10-methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms in rheumatoid arthritis (RA) patients with (+) or without (-) cardiovascular events in the whole cohort and in patients with 10 years follow up. Ref., reference.