Table 2.
Relationship of relDAS28 and single-nucleotide polymorphism genotypes and comparison of allele frequencies between responders and non-responders
| Single-nucleotide polymorphisms | P value of relDAS28 | MAF of responders, percentage (n/N) | MAF of non-responders, percentage (n/N) | ORa(95% CI) | P value |
|---|---|---|---|---|---|
| rs983332 | 0.6 | 25.9 (30/116) | 27.9 (19/68) | 1.11 (0.6-2.0) | 0.8 |
| rs928655 | 0.1 | 18.9 (23/122) | 28.0 (19/68) | 0.60 (0.3-1.2) | 0.1 |
| rs13393173 | 0.8 | 23.8 (29/122) | 20.6 (14/68) | 0.83 (0.4-1.7) | 0.6 |
| rs437943 | 0.05 | 38.5 (47/122) | 25.0 (17/68) | 0.53 (0.3-1.0) | 0.06 |
| rs10945919 | 0.7 | 27.9 (34/122) | 23.5 (16/68) | 0.79 (0.4-1.7) | 0.5 |
| rs854547 | 0.3 | 39.3 (48/122) | 36.8 (25/68) | 1.12 (0.6-2.1) | 0.7 |
| rs854548 | 0.9 | 23.0 (28/122) | 23.5 (16/68) | 1.03 (0.5-2.0) | 0.9 |
| rs854555 | 0.6 | 35.2 (43/122) | 38.2 (26/68) | 1.14 (0.6-2.0) | 0.7 |
| rs868856 | 0.6 | 32.8 (40/122) | 36.8 (25/68) | 1.19 (0.6-2.0) | 0.6 |
| rs7046653 | 0.5 | 32.0 (39/122) | 36.8 (25/68) | 1.23 (0.7-2.5) | 0.5 |
| rs2814707 | 0.8 | 25.4 (31/122) | 29.4 (20/68) | 1.22 (0.6-2.5) | 0.6 |
| rs3849942 | 0.4 | 23.0 (28/122) | 29.4 (20/68) | 1.41 (0.7-2.5) | 0.3 |
| rs774359 | 0.2 | 26.2 (32/122) | 36.8 (25/68) | 1.64 (0.8-3.3) | 0.1 |
| rs6138150 | 0.5 | 14.0 (17/122) | 14.7 (10/68) | 0.94 (0.4-2.2) | 0.9 |
| rs6028945 | 0.9 | 12.3 (15/122) | 13.2 (9/68) | 1.09 (0.5-2.5) | 0.9 |
| rs6071980 | 0.9 | 18.9 (23/122) | 16.2 (11/68) | 0.83 (0.4-2.0) | 0.6 |
aOdds ratios (ORs) were calculated as in Liu and colleagues [7], taking the allele associated with the non-responders in that report as the numerator of the odds, and the non-responder odds as the numerator of the OR. CI, confidence interval; MAF, minor allele frequency; n, number of minor alleles; N, total number of alleles; relDAS28, relative change in disease activity score using 28 joint counts between baseline and time of evaluation.