Fig. 5.
Slack-specific RNAi eliminates a component of outward current in cultured primary OB mitral cells. A and C: representative whole cell currents under control (control) or RNAi-2757 transfected conditions (Slack RNAi) using neurons from wildtype (wt) or Kv1.3−/− mice. Currents were recorded with an internal solution containing 60 mM Na+ ion and evoked by stepping from −80 mV to test potentials of −80, −50, 10, 40, and 70 mV for 400 ms. B and D: grouped I–V relations in the absence or presence of RNAi-2757 (n = 7, 9 and 5, 7, respectively).