Table 3.

Selected regions of interest for the entire learning period

LEFT			MEDIAL			RIGHT
Region of Interest	Talairach Location	Signal Change	Region of Interest	Talairach Location	Signal Change	Region of Interest	Talairach Location	Signal Change
FP	[11 −60 2]	5.6282***	dACC	[−4 −20 36]	3.4971**	FP	[−6 −64 2]	2.7404*
PFC	[25 −35 36]	3.4690**	vACC	[0 −33 11]	−2.8287*	PFC	[−6 −35 36]	2.2940*
dlPFC	[24 −23 51]	2.3046*	pSMA	[5 −9 57]	—	dlPFC	[−32 −19 51]	4.1424**
dlPMC	[26 5 50]	0.2530*				dlPMC	[−24 4 50]	—
M1	[43 13 50]	—				MI	[−43 13 50]	—
SPL	[18 62 50]	3.3689**				SPL	[−30 54 50]	2.2468*
FCS LING	[33 81 −14]	3.2466**				FUS LING	[−31 82 −14]	3.1359**
MT/VS	[40 68 2]	2.2273*				MT/V5	[−46 64 2]	—
hCN	[7 −15 2]	−3.5063**				hCN	[−7 −15 2]	—
aPUT	[30 −4 2]	—				aPUT	[−21 −5 2]	—
TH	[8 6 10]	−2.3486*				TH	[−8 6 10]	—
aVER	[8 35 −18]	−3.0715*				aVER	[−8 35 −18]	−3.5034**
						DN	[−25 45 −29]	−3.6031**

—, P > 0.05;

^*P < 0.05;

^**P < 0.01;

^***P < 0.001;

****, P < 0.0001.

All coordinates are in Talairach space. The analysis of the entire learning period. Each voxel was compared with the average jerk (Njerk) learning curve from the kinematic analysis. Significant positive values (in bold) are those areas that fit this curve, being high early and decreasing in a double exponential manner as graphomotor sequence learning progressed. Significant negative values were the inverse: low early, with progressively higher activity later in learning.

FP, frontal pole; PFC, prefrontal cortex; dlPFC, dorsolateral PFC; dlPMC, dorsolateral premotor cortex; M1, primary motor cortex; SPL, superior parietal lobule; FUS/LING, fusiform gyrus/lingual gyrus; MT/V5, medial temporal lobe/visual area 5; hCN, head of the caudate nucleus; a PUT, anterior putamen; TH, thalamus; aVER, anterior vermis; dACC and vACC, dorsal and ventral anterior cingulate cortex; pSMA, presupplementary motor cortex; DN, deatate nucleus.