Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Illustration of the wild type hMC4R full agonist and partial agonist activity of the endogenous melanocortin agonists at the E61K, D90N, Y157S, and C271R hMC4Rs. The ligand efficacy is relative to non-receptor dependent maximal stimulation by the forskolin control compound which is defined as 1.0 on the Y-axis.
