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Illustration of the hAGRP(87-132) antagonist pharmacology at the wild type (WT), E61K, D90N, Y157S, and C271R hMC4Rs. The MTII ligand is a full agonist at the WT hMC4R and a partial agonist at the E61K, D90N, Y157S, and C271R hMC4Rs relative to non-receptor dependent maximal stimulation by the forskolin control compound which is defined as 1.0 on the Y-axis.
