Table 5.
Summary of the hMC4R polymorphism and if they were observed in obese versus non-obese patients.
| Mutation | Genotype | Non-Obese Patient | Obese Patient | Ref |
|---|---|---|---|---|
| R7H | Heterozygous | X | (71) | |
| R18H | Unable to determine | X | (52) | |
| R18L | Unable to determine | X | (71) | |
| S36Y | Unable to determine | X | (55) | |
| P48S | Heterozygous | X | (72) | |
| V50M | Heterozygous | X | (58) | |
| F51L | Heterozygous | X | (73) | |
| E61K | Heterozygous | X | (74) | |
| I69T | Heterozygous | X | (74) | |
| D90N | Heterozygous | X | (66) | |
| S94R | Unable to determine | X | (75) | |
| G98R | Heterozygous & Homozygous | X | (76) | |
| I121T | Unable to determine | X | (75) | |
| A154D | Heterozygous | X | (77) | |
| Y157S | Homozygous | X | (78) | |
| W174C | Heterozygous | X | (79) | |
| G181D | Heterozygous | X | (55, 75) | |
| F202L | Heterozygous | X% | X# | %(54)#(74) |
| A219V | Unable to determine | X | (55) | |
| I226T | Heterozygous | X | (80, 81) | |
| G231S | Heterozygous | X | (82) | |
| G238D | Heterozygous | X | (74) | |
| N240S | Heterozygous | X | (54) | |
| 750DELGA | Homozygous | X | (75) | |
| C271R | Homozygous | X | (74) | |
| S295P | Heterozygous | X | (77) | |
| P299L | Heterozygous | X | (80) | |
| E308K | Heterozygous | X | (83) | |
| I317V | Heterozygous | X | (75, 79) | |
| L325F | Unable to determine | X | (55) |