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. 2010 Apr 23;285(26):19738–19746. doi: 10.1074/jbc.M110.101287

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© 2010 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 4. — HMW complex formation of TMD-swap PS1 mutants. A, BN-PAGE analysis of digitonin-solubilized lysate prepared from DKO cells expressing mock or WT PS1. Antibodies used as well as target proteins are indicated below the panel. Note that the overexpression of PS1 in DKO cells restored the formation of the HMW complex that migrated at 440 kDa. B, BN-PAGE analysis of mutant PS1. SPP was used as loading control as SPP was detected at 200 kDa in this analysis irrespective of PS1 overexpression.