TABLE 1.

Susceptibility to sinefungin and kinetic properties of S-adenosylmethionine transport in Leishmania spp.

The IC₅₀ values are 50% inhibitory concentrations of sinefungin. The means ± S.D. of at least three independent experiments are given.

Strains	IC50 value of sinefungin	Km	Vmax
	nm	nm	pmol/108 cells/min
L. infantum MHOM/MA/67/ITMAP-263	80 ± 18	167 ± 27	0.56 ± 0.17
L. infantum JPCM5	2000 ± 300	180 ± 82	0.05 ± 0.01
L. major LV39	50 ± 4	252 ± 10	0.57 ± 0.13
L. major Friedlin	>6000	320 ± 7	0.03 ± 0.01
LV39SNF4000.4 + AdoMetT1-GFP	10 ± 2	284 ± 72	0.58 ± 0.24