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The tumorigenicity of NPM-ALK, but not that of NPM-ALKY343F, was suppressed by SHP1, as assessed by soft agar clonogenic assay. The colony formation induced by NPM-ALK in GP293 cells was significantly reduced by SHP1 (p = 0.0032). In contrast, the colony formation induced by NPM-ALKY343F was not significantly affected by SHP1 (p > 0.05). These experiments were performed in triplicates.
