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SpARC4 is a multifunctional ADP-ribosyl cyclase. A and B, homogenates prepared from Xenopus embryos expressing SpARC4 Myc were incubated with 1 mm NAD (A) or 1 mm NADP + 50 mm nicotinic acid (NA) (B) and the reaction mixtures separated by HPLC. Typical chromatograms after a 0.1-h (black traces) or 3-h (red traces) incubation are shown. C and D, time courses for production of cADPR (circles) and NAADP (squares) by Xenopus embryo homogenates expressing SpARC4 Myc (C) and SpARC2 Myc (D).
